potential spoilers below
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so far it has been heavily rumored that a death will occur in the next episode, and since it looks to be mainly just about Daryl and Beth my guess is one of them is going to die.
I want to say Daryl dies (he has faded too much for me + it would be 100x more interesting), but Beth has such a bigger role in their partnership so I don't know
The spoiling dead people sometimes go to the set and they saw a pic where Daryl was carrying Beth through a graveyard. Beth is the most likely to die in S4.